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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

2-AMINO-5-NITROTHIAZOLE

VOL.: 31 (1983) (p. 71)

CAS No.: 121-66-4
Chem. Abstr. Name: 2-Thiazolamine, 5-nitro-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

2-Amino-5-nitrothiazole was tested for carcinogenicity in one experiment in mice and in two experiments in two strains of rats by administration in the diet. In one experiment in female rats, 2-amino-5-nitrothiazole increased the incidence of benign mammary tumours. In the other experiment in rats it increased the incidences of malignant lymphomas, lymphocytic and undifferentiated leukaemias, and granulocytic leukaemias in male rats. The results of studies in mice were not indicative of a carcinogenic effect.

2-Amino-4-nitrothiazole was mutagenic in bacteria. The data were inadequate to evaluate the activity of this compound in short-term tests.

No data were available to evaluate the teratogenicity of this compound to experimental animals.

5.2 Human data

2-Amino-5-nitrothiazole, a synthetic veterinary antiprotozoal agent, has been produced and used since 1950. It is also used as an intermediate in the manufacture of disperse azo dyes. Manufacturers of the compound itself, handlers of feed and people involved in the synthesis of the dyes concerned are exposed to 2-amino-5-nitrothiazole.

No data were available to assess the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of 2-amino-5-nitrothiazole was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of 2-amino-5-nitrothiazole in experimental animals. In the absence of epidemiological data, no evaluation of the carcinogenicity of 2-amino-5-nitrothiazole to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 3)

Synonyms


Last updated: 16 April 1998






















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