IPCS INCHEM Home

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

AF-2 [2-(2-FURYL)-3-(5-NITRO-2-FURYL)ACRYLAMIDE]

VOL.: 31 (1983) (p. 47)

CAS No.: 3688-53-7
Chem. Abstr. Name: 2-Furanacetamide, a-[(5-nitro-2-furanyl)methylene]-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

AF-2 was tested for carcinogenicity in three experiments in mice, in two experiments in rats and in two experiments in hamsters by administration in the diet. It produced benign and malignant forestomach tumours in mice of both sexes, benign and malignant mammary tumours and forestomach papillomas in rats of both sexes and benign and malignant forestomach tumours in hamsters of both sexes and oesophageal tumours in male hamsters. In one experiment in weanling mice by subcutaneous injection, it produced lung tumours. It produced multiple lung tumours in the offspring of mice treated subcutaneously during pregnancy.

AF-2 induced DNA damage in bacteria and in human cells and mutations in bacteria, fungi, insects and mammalian cells in vivo and in vitro. It caused chromosomal anomalies in mammalian cells, including human cells. AF-2 caused neoplastic transformation in hamster cells. There is sufficient evidence that AF-2 is active in short-term tests.

AF-2 induced foetal deaths in mice and was teratogenic to survivors of dams pretreated with phenobarbital.

5.2 Human data

AF-2 has been used in Japan since at least 1965, but it is not used presently. Its use as a food preservative was a source of exposure for the general population.

No data were available to assess the teratogenicity or chromosomal effects of this compound in humans.

The one available epidemiological study in which a regional correlation between AF-2 consumption and breast cancer mortality was analysed was considered inadequate to evaluate the carcinogenicity of AF-2.

5.3 Evaluation

The epidemiological data were inadequate to evaluate the carcinogenicity of AF-2 to humans.

There is sufficient evidence for the carcinogenicity of AF-2 in experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 56: Group 2B)

Synonyms


Last updated: 16 April 1998






















    See Also:
       Toxicological Abbreviations