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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

KAEMPFEROL

VOL.: 31 (1983) (p. 171)

CAS No.: 520-18-3
Chem. Abstr. Name: 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Kaempferol was tested for carcinogenicity in one experiment in rats by administration in the diet. The data are inadequate to make an evaluation.

Kaempferol was mutagenic in bacteria and insects and in mammalian cells in vitro; it induced micronuclei in mice. There is limited evidence that kaempferol is active in short-term tests.

No data were available to evaluate the teratogenicity of kaempferol to experimental animals.

5.2 Human data

The natural occurrence of kaempferol, an aglycone widely distributed in fruit and other edible plants, results in wide human exposure to this compound.

No data were available to evaluate the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of kaempferol was available to the Working Group.

5.3 Evaluation

The available data were inadequate to evaluate the carcinogenicity of kaempferol to experimental animals. In the absence of epidemiological data, no evaluation of the carcinogenicity of kaempferol to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 65: Group 3)

Synonyms


Last updated: 16 April 1998






















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