International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 31 (1983) (p. 179)
CAS No.: 139-94-6
Chem. Abstr. Name: Urea, N-ethyl-N'-(5-nitro-2-thiazolyl)-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Nithiazide was tested for carcinogenicity in one experiment in
mice and in one experiment in rats by administration in the diet. It
increased the incidence of hepatocellular carcinomas and adenomas in
male mice. In female rats, it increased the incidences of
fibroadenomas and cystadenomas of the skin, subcutaneous tissue and
mammary gland (significant only if individual incidences for each site
were combined) and the incidence of endometrial stromal polyps of the
No data were available to assess the mutagenic or teratogenic
effects of nithiazide in experimental systems.
5.2 Human data
Nithiazide, a synthetic antiprotozoal agent, was first produced
in 1961. Humans may be exposed as a result of its manufacture and use
in veterinary medicine.
No data were available to assess the teratogenicity or
chromosomal effects of this compound in humans.
No case report or epidemiological study of the carcinogenicity of
nithiazide was available to the Working Group.
There is limited evidence for the carcinogenicity of nithiazide
in experimental animals. In the absence of epidemiological data no
evaluation of the carcinogenicity of nithiazide to humans could be
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)
- Hepzide 30
Last updated: 16 April 1998