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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

PETASITENINE

VOL.: 31 (1983) (p. 207)

CAS No.: 60102-37-6
Chem. Abstr. Name: 4,8-Secosenecionan-8,11,16-trione, 15,20-epoxy-15,20-dihydro-
12-hydroxy-4-methyl-,(15b,20R)-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Petasitenine isolated from young flower stalks of wild Petasites japonicus Maxim. was tested for carcinogenicity in rats by administration in the drinking-water; haemangioendothelial sarcomas of the liver and liver-cell adenomas were observed. Flower stalks of Petasites japonicus Maxim. were tested in mice, rats and hamsters by administration in the diet. They increased the incidence of lung adenomas and adenocarcinomas in mice of one strain and of haemangioendothelial sarcomas of the liver and of hepatocellular adenomas and hepatocellular carcinomas in rats. No increase in tumour incidence was observed in hamsters.

Petasitenine is mutagenic in bacteria and in mammalian cells in vitro. It also induced chromosomal aberrations, unscheduled DNA synthesis and transformation in mammalian cells in vitro. There is sufficient evidence that petasitenine is active in short-term tests.

No data were available to evaluate the teratogenicity of this compound to experimental animals.

5.2 Human data

Petasitenine is found in a plant species to which limited human exposure occurs from its use as a herbal remedy and as a food.

No data were available to evaluate the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of petasitenine was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of both petasitenine and flower stalks of Petasites japonicus Maxim. in experimental animals. In the absence of epidemiological data, no evaluation of the carcinogenicity of petasitenine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 69: Group 3)

Synonym


Last updated: 16 April 1998






















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