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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

TRP-P-2 (3-AMINO-1-METHYL-5H-PYRIDO[4,3-b]INDOLE)
AND ITS ACETATE

VOL.: 31 (1983) (p. 255)

Trp-P-2
CAS No.: 62450-07-1
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1-methyl-

Trp-P-2 acetate
CAS No.:75104-43-7
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1-methyl-, monoacetate

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Trp-P-2 was tested for carcinogenicity in mice and rats by administration in the diet, in mice by skin application and bladder implantation and in rats and hamsters by subcutaneous administration. An increased incidence of liver tumours was observed in female mice and female rats following its oral administration. Bladder carcinomas were observed in female mice after implantation of Trp-P-2 in paraffin pellets at this site. The results of the experiments by subcutaneous injection and by skin application were considered inadequate for evaluation.

Trp-P-2 is mutagenic to Salmonella typhimurium following metabolic activation. It induced chromosomal anomalies in mammalian cells, including human cells, in vitro. It caused neoplastic transformation in vitro in Syrian golden hamster cells. There is sufficient evidence that Trp-P-2 is active in short-term tests.

No data were available to evaluate the teratogenicity of this compound to experimental animals.

5.2 Human data

Trp-P-2 is found in the charred fraction of cooked fish, and the consumption of this food is a source of exposure for the general population.

No data were available to evaluate the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of Trp-P-2 was available to the Working Group.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of Trp-P-2 in experimental animals. No data on humans were available.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 2B)

Synonyms for Trp-P-2

Synonym for Trp-P-2 acetate


Last updated: 16 April 1998






















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       Toxicological Abbreviations