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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

1-METHYLPHENANTHRENE

VOL.: 32 (1983) (p. 405)

CAS No.: 832-69-9
Chem. Abstr. Name: Phenanthrene, 1-methyl-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

1-Methylphenanthrene was tested in the mouse-skin initiation-promotion assay in one study and was inactive as an initiator.

No data on the teratogenicity of this chemical were available.

1-Methylphenanthrene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. It induced unscheduled DNA synthesis in cultured primary hepatocytes from rats and was mutagenic to human lymphoblasts in vitro in the presence of an exogenous metabolic system.

There is sufficient evidence that 1-methylphenanthrene is active in short-term tests.

5.2 Human data

1-Methylphenanthrene is present as a major component of the total content of polynuclear aromatic compounds in the environment. Human exposure to 1-methylphenanthrene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

The available data are inadequate to permit an evaluation of the carcinogenicity of 1-methylphenanthrene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 3)


Last updated: 17 April 1998






















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