VOL.: 32 (1983) (p.135)
Chem. Abstr. Name: Benz(a)anthracene
The available data on reproductive toxicity and teratogenicity were inadequate for evaluation.
Benz[a]anthracene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system and was mutagenic to Drosophila melanogaster; it was also mutagenic to mammalian cells in vitro in the presence of an exogenous metabolic system. This compound was positive in one study of sister chromatid exchange. It induced unscheduled DNA synthesis in cultured mammalian cells and morphological transformation. In one in-vivo study, it induced sister chromatid exchange in hamsters; reports from in-vivo studies on the induction of chromosomal aberrations were conflicting.
There is sufficient evidence that benz[a]anthracene is active in short-term tests.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2A)
See Also: Toxicological Abbreviations