VOL.: 32 (1983) (p. 211)
Chem. Abstr. Name: Benzo(a)pyrene
Benzo[a]pyrene is embryotoxic and teratogenic in mice; the inducibility of aryl hydrocarbon hydroxylase activity in dams and fetuses is an important factor in determining these effects. A reduction in fertility in both male and female offspring was observed in mice following exposure to benzo[a]pyrene in utero.
Benzo[a]pyrene undergoes metabolism to reactive electrophiles capable of binding covalently to DNA. It was active in assays for bacterial DNA repair, bacteriophage induction and bacterial mutation; mutation in Drosophila melanogaster; DNA binding, DNA repair, sister chromatid exchange, chromosomal aberrations, point mutation and transformation in mammalian cells in culture; and in tests in mammals in vivo, including DNA binding, sister chromatid exchange, chromosomal aberration, sperm abnormality and the somatic specific locus (spot) test.
There is sufficient evidence that benzo[a]pyrene is active in short-term tests.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2A)
See Also: Toxicological Abbreviations Benzo[a]pyrene (WHO Food Additives Series 28) BENZO[a]PYRENE (JECFA Evaluation)