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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BENZO[c]PHENANTHRENE

VOL.: 32 (1983) (p. 205)

CAS No.: 195-19-7
Chem. Abstr. Name: Benzo(c)phenanthrene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benzo[c]phenanthrene was tested in a mouse-skin initiation-promotion assay and was active as an initiator. Other experiments in mice by skin application and in mice and rats by subcutaneous injection were considered inadequate for evaluation.

No data on the teratogenicity of this chemical were available.

In the one study evaluated, benzo[c]phenanthrene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that benzo[c]phenanthrene is active in short-term tests.

5.2 Human data

Benzo[c]phenanthrene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benzo[c]phenanthene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

The available data are inadequate to permit an evaluation of the carcinogenicity of benzo[c]phenanthrene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)

Synonyms


Last updated: 17 April 1998






















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