International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 163)
CAS No.: 207-08-9
Chem. Abstr. Name: Benzo(k)fluoranthene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Benzo[k]fluoranthene was tested for carcinogenicity in females of
two strains of mice by skin application and produced a few skin
tumours. It was also tested in a mouse-skin initiation-promotion
assay and was active as an initiator. In one experiment involving
subcutaneous injection of benzo[k]fluoranthene to mice, it produced
sarcomas at the site of injection. Benzo[k]fluoranthene produced
squamous-cell carcinomas of the lung in rats in a dose-related manner
following its direct injection into pulmonary tissue.
No data on the teratogenicity of this compound were available.
Benzo[k]fluoranthene was mutagenic to Salmonella typhimurium in
the presence of an exogenous metabolic system.
There is inadequate evidence that benzo[k]fluoranthene is active
in short-term tests.
5.2 Human data
Benzo[k]fluoranthene is present as a component of the total
content of polynuclear aromatic compounds in the environment. Human
exposure to benzo[k]fluoranthene occurs primarily through the smoking
of tobacco, inhalation of polluted air and by ingestion of food and
water contaminated by combustion effluents.
There is sufficient evidence that benzo[k]fluoranthene is
carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2B)
Last updated: 17 April 1998