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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BENZO[k]FLUORANTHENE

VOL.: 32 (1983) (p. 163)

CAS No.: 207-08-9
Chem. Abstr. Name: Benzo(k)fluoranthene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benzo[k]fluoranthene was tested for carcinogenicity in females of two strains of mice by skin application and produced a few skin tumours. It was also tested in a mouse-skin initiation-promotion assay and was active as an initiator. In one experiment involving subcutaneous injection of benzo[k]fluoranthene to mice, it produced sarcomas at the site of injection. Benzo[k]fluoranthene produced squamous-cell carcinomas of the lung in rats in a dose-related manner following its direct injection into pulmonary tissue.

No data on the teratogenicity of this compound were available.

Benzo[k]fluoranthene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that benzo[k]fluoranthene is active in short-term tests.

5.2 Human data

Benzo[k]fluoranthene is present as a component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benzo[k]fluoranthene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

There is sufficient evidence that benzo[k]fluoranthene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2B)

Synonyms


Last updated: 17 April 1998






















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