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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CARBAZOLE

VOL.: 32 (1983) (p. 239)

CAS No.: 86-74-8
Chem. Abstr. Name: 9H-Carbazole

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Carbazole was tested for carcinogenicity in mice by administration in the diet, by skin application and by subcutaneous injection. In the study by oral administration, a dose-dependent increase in the incidence of liver neoplastic nodules and hepatocellular carcinomas was observed. Papillomas and carcinomas of the forestomach occurred in animals receiving the high-dose level. The other studies in mice were considered inadequate for evaluation.

No data on the teratogenicity of this compound were available.

Carbazole was not mutagenic to Salmonella typhimurium.

There is inadequate evidence that carbazole is active in short-term tests.

5.2 Human data

Carbazole is present as a major component of the total content of polynuclear aromatic compounds in the environment, arising primarily from the combustion of tobacco and coal.

5.3 Evaluation

There is limited evidence that carbazole is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonyms


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       Carbazole  (IARC Summary & Evaluation, Volume 71, 1999)