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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CORONENE

VOL.: 32 (1983) (p. 263)

CAS No.: 191-07-1

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Coronene was tested for carcinogenicity in one experiment in mice by skin application. No significant increase in the incidence of skin tumours was observed. It was also tested in the mouse-skin initiation-promotion assay and was active as an initiator.

No data on the teratogenicity of this compound were available.

Coronene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that coronene is active in short-term tests.

5.2 Human data

Coronene is present as a minor component of the total content of polynuclear aromatic compounds in the environment; it is a major component of the polycyclic aromatic compound content of gasoline engine exhaust.

5.3 Evaluation

The available data are inadequate to permit an evaluation of the carcinogenicity of coronene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)

Synonym


Last updated: 17 April 1998






















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