International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 263)
CAS No.: 191-07-1
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Coronene was tested for carcinogenicity in one experiment in mice
by skin application. No significant increase in the incidence of skin
tumours was observed. It was also tested in the mouse-skin
initiation-promotion assay and was active as an initiator.
No data on the teratogenicity of this compound were available.
Coronene was mutagenic to Salmonella typhimurium in the presence
of an exogenous metabolic system.
There is inadequate evidence that coronene is active in
5.2 Human data
Coronene is present as a minor component of the total content of
polynuclear aromatic compounds in the environment; it is a major
component of the polycyclic aromatic compound content of gasoline
The available data are inadequate to permit an evaluation of the
carcinogenicity of coronene to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)
Last updated: 17 April 1998