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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DIBENZ[a,j]ACRIDINE

VOL.: 32 (1983) (p. 283)

CAS No.: 224-42-0
Chem. Abstr. Name: Dibenz(a,j)acridine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Dibenz[a,j]acridine has been shown to be carcinogenic to experimental animals.

No data on the teratogenicity of this compound were available.

Dibenz[a,j]acridine was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. It did not induce unscheduled DNA synthesis in rat hepatocytes.

There is inadequate evidence that dibenz[a,j]acridine is active in short-term tests.

5.2 Human data

Dibenz[a,j]acridine occurs in tobacco smoke and urban pollutants.

5.3 Evaluation

There is sufficient evidence that dibenz[a,j]acridine is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 3 (1973)

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 2B)

Synonyms


Last updated: 17 April 1998






















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       Toxicological Abbreviations