International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 343)
CAS No.: 191-30-0
Chem. Abstr. Name: Dibenzo(def,p)chrysene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Dibenzo[a,l]pyrene was tested for carcinogenicity in mice in one
study by skin application and in one study by subcutaneous
administration. It induced tumours at the sites of application.
No data on the teratogenicity of this compound were available.
No data were available to evaluate the activity of
dibenzo[a,l]pyrene in short-term tests.
5.2 Human data
Dibenzo[a,l]pyrene is present as a minor component of the total
content of polynuclear aromatic compounds in the environment. Human
exposure to dibenzo[a,l]pyrene occurs mainly through the smoking of
tobacco, inhalation of polluted air and by ingestion of food and water
contaminated with combustion products.
There is sufficient evidence that dibenzo[a,l]pyrene is
carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 2B)
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Last updated: 17 April 1998