International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 373)
CAS No.: 193-39-5
Chem. Abstr. Name: Indeno(1,2,3-cd)pyrene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Indeno[l,2,3-cd]pyrene has been shown to be carcinogenic to
experimental animals (see 'General Remarks on the Substances
Considered', in this volume and IARC, 1973).
No data on the teratogenicity of this compound were available.
Indeno[l,2,3-cd]pyrene was mutagenic to Salmonella typhimurium in
the presence of an exogenous metabolic system.
There is inadequate evidence that indeno[1,2,3-cd]pyrene is
active in short-term tests.
5.2 Human data
Indeno[1,2,3-cd]pyrene is present as a component of the
polynuclear aromatic compound content in the environment. Human
exposure to indeno[1,2,3-cd]pyrene occurs primarily through the
smoking of tobacco, inhalation of polluted air and by ingestion of
food and water contaminated by combustion effluents.
There is sufficient evidence that indeno[1,2,3-cd]pyrene is
carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 2B)
Last updated: 18 April 1998