International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 411)
CAS No.: 198-55-0
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Perylene was tested for carcinogicity by skin application to mice
in one experiment, and no carcinogenic effect was observed. It was
also tested in the mouse-skin initiation-promotion assay in one study,
with negative results.
No data on the teratogenicity of this compound were available.
Perylene was mutagenic to Salmonella typhimurium in the presence
of an exogenous metabolic system. In one study, it did not induce
mutations in cultured human lymphoblastoid cells. The data from one
study on chromosomal effects were inadequate to make an evaluation.
There is inadequate evidence that perylene is active in
5.2 Human data
Perylene is present as a minor component of the total content of
polynuclear aromatic compounds of the environment. Human exposure to
perylene occurs primarily through the smoking of tobacco, inhalation
of polluted air and by ingestion of food and water contaminated with
The available data are inadequate to permit an evaluation of the
carcinogenicity of perylene in experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 69: Group 3)
Last updated: 17 April 1998