VOL.: 32 (1983) (p. 419)
Phenanthrene administered by intraperitoneal or subcutaneous injection to neonatal mice did not increase the incidence of tumours over that in controls. Experiments involving a single oral administration to rats and a single subcutaneous injection to mice were inadequate for evaluation.
No data on the teratogenicity of this compound were available.
Phenanthrene has generally been reported to be non-mutagenic to Salmonella typhimurium; however, in one study it was reported to be mutagenic to Salmonella typhimurium in the presence of a high concentration of an exogenous metabolic system. It gave negative results in an assay for differential survival using DNA-repair-proficient/-deficient strains of Bacillus subtilis. It did not induce DNA repair, chromosomal aberrations or sister chromatid exchange in cultured mammalian cells. It did induce mutation in one experiment in human cells in culture in the presence of an exogenous metabolic system, and induced sister chromatid exchange in Chinese hamster bone-marrow cells in vivo. The compound failed to induce morphological transformation.
There is limited evidence that phenanthrene is active in short-term tests.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 69: Group 3)
See Also: Toxicological Abbreviations