International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 36 (1985) (p. 39)
CAS No.: 107-05-1
Chem. Abstr. Name: 1-Propene, 3-chloro-
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Allyl chloride has been produced commercially since 1945 and is
used almost exclusively as a chemical intermediate, principally in the
production of epichlorohydrin.
5.2 Experimental data
Allyl chloride has been tested for carcinogenicity by intragastric
intubation in mice and rats, by skin application in mice, both by
repeated application and in a two-stage assay, and by intraperitoneal
injection in mice. Following its oral administration to mice, a
nonsignificant increase in the incidence of squamous-cell papillomas
and carcinomas of the forestomach was observed; the experiment in
rats was inadequate for evaluation. No skin tumour was observed in
mice following repeated skin applications; however, a single
application followed by treatment with 12-0-tetradecanoylphorbol
13-acetate gave some evidence that allyl chloride acts as an
initiator. Following its intraperitoneal injection to strain A mice,
a slight increase in the incidence of lung adenomas was observed.
Inhalation exposure to allyl chloride of high purity did not
induce teratogenicity in rats or rabbits.
Allyl chloride caused DNA damage in bacteria, and was mutagenic to
bacteria and fungi.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
allyl chloride to humans was available to the Working Group.
There is inadequate evidence for the carcinogenicity of allyl
chloride in experimental animals.
In the absence of epidemiological data, no evaluation could be
made of the carcinogenicity of allyl chloride to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
- 2-Propenyl chloride
Last updated: 13 April 1999