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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

ALLYL CHLORIDE

VOL.: 36 (1985) (p. 39)

CAS No.: 107-05-1
Chem. Abstr. Name: 1-Propene, 3-chloro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Allyl chloride has been produced commercially since 1945 and is used almost exclusively as a chemical intermediate, principally in the production of epichlorohydrin.

5.2 Experimental data

Allyl chloride has been tested for carcinogenicity by intragastric intubation in mice and rats, by skin application in mice, both by repeated application and in a two-stage assay, and by intraperitoneal injection in mice. Following its oral administration to mice, a nonsignificant increase in the incidence of squamous-cell papillomas and carcinomas of the forestomach was observed; the experiment in rats was inadequate for evaluation. No skin tumour was observed in mice following repeated skin applications; however, a single application followed by treatment with 12-0-tetradecanoylphorbol 13-acetate gave some evidence that allyl chloride acts as an initiator. Following its intraperitoneal injection to strain A mice, a slight increase in the incidence of lung adenomas was observed.

Inhalation exposure to allyl chloride of high purity did not induce teratogenicity in rats or rabbits.

Allyl chloride caused DNA damage in bacteria, and was mutagenic to bacteria and fungi.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of allyl chloride to humans was available to the Working Group.

5.4 Evaluation

There is inadequate evidence for the carcinogenicity of allyl chloride in experimental animals.

In the absence of epidemiological data, no evaluation could be made of the carcinogenicity of allyl chloride to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonyms

Last updated: 13 April 1999 






























    See Also:
       Toxicological Abbreviations
       Allyl chloride (ICSC)
       Allyl Chloride  (IARC Summary & Evaluation, Volume 71, 1999)