International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 36 (1985) (p. 69)
CAS No.: 2835-39-4
Chem. Abstr. Name: Butanoic acid, 3-methyl-, 2-propenyl ester
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Allyl isovalerate has been used since the 1950s as a fragrance raw
material in cosmetics, lotions and perfumes and in certain food
products, although it is not known whether it is used in these
5.2 Experimental data
Allyl isovalerate was tested for carcinogenicity by intragastric
intubation in mice of one strain and in rats of one strain. In mice,
it induced papillomas of the forestomach in males and increased the
incidence of lymphomas in females. In rats an increased incidence of
mononuclear-cell leukaemia was observed in animals of both sexes.
Allyl isovalerate was not mutagenic to bacteria.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
allyl isovalerate to humans was available to the Working Group.
There is limited evidence for the carcinogenicity of allyl
isovalerate to experimental animals.
In the absence of epidemiological data, no evaluation could be
made of the carcinogenicity of allyl isovalerate to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
- Allyl isovalerianate
- Allyl 3-methylbutyrate
- FEMA No. 2045
- Isovaleric acid, allyl ester
- 3-Methylbutanoic acid, 2-propenyl ester
- 3-Methylbutyric acid, allyl ester
- 2-Propenyl isovalerate
- 2-Propenyl 3-methylbutanoate
Last updated: 13 April 1999