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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DIGLYCIDYL RESORCINOL ETHER

VOL.: 36 (1985) (p. 181)

CAS No.: 101-90-6
Chem. Abstr. Name: Oxirane, 2,2'-[1,3-phenylenebis(oxymethylene)]bis-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Diglycidyl resorcinol ether has been produced since at least 1974. It has only limited application, principally in the aerospace industry.

5.2 Experimental data

Diglycidyl resorcinol ether (of technical grade) was tested for carcinogenicity by intragastric intubation in mice of one strain and in rats of one strain. It induced squamous-cell carcinomas and papillomas of the forestomach in animals of both species. In female mice, an increased incidence of hepatocellular tumours was observed. In one experiment in mice, no skin tumour was observed after skin application.

Diglycidyl resorcinol ether (of technical grade) was mutagenic to bacteria.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of diglycidyl resorcinol ether to humans was available to the Working Group.

5.4 Evaluation

There is sufficient evidence for the carcinogenicity of a technical grade of diglycidyl resorcinol ether to experimental animals.

No data on the carcinogenicity of diglycidyl resorcinol ether to humans were available to the Working Group.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 11 (1976)

Subsequent evaluation: Vol. 71 (1999)

Synonyms


Last updated: 13 April 1999






















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       Toxicological Abbreviations