International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 37 (1985) (p. 205)
CAS No.: 64091-90-3
Chem. Abstr. Name: 3-Pyridinebutanal, g-(methylnitrosoamino)-
5. Summary of Data Reported and Evaluation
No analytical evidence was found that
4-(methylnitrosamino)-4-(3-pyridyl)butanal (NNA) occurs in tobacco or
in the saliva of snuff users, although, under certain laboratory
conditions, its formation from nicotine has been observed.
5.2 Experimental data
NNA was tested by intraperitoneal injection in female mice of one
strain at one dose level only. Although the incidence of lung
adenomas in treated mice exceeded those in controls, the experiment
does not allow an evaluation of the carcinogenicity of NNA.
No data were available on mutagenic or related effects of NNA.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
NNA to humans was available to the Working Group.
The available data are inadequate to evaluate the carcinogenicity of 4-(methylnitrosamino)-4-
(3-pyridyl)butanol to experimental animals.
No data on humans were available.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 3)
Last updated: 21 April 1998