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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

11-AMINOUNDECANOIC ACID

VOL.: 39 (1986) (p. 239)

CAS No.: 2432-99-7
Chem. Abstr. Name: Undecanoic acid, 11-amino-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

11-Aminoundecanoic acid is synthesized by one company for the production of Nylon 11.

5.2 Experimental data

11-Aminoundecanoic acid was tested for carcinogenicity in mice and rats by administration in the diet. Increased incidences of transitional-cell carcinomas of the urinary bladder and neoplastic nodules of the liver were observed in male rats. Transitional-cell carcinomas of the kidney and epithelial hyperplasia of the urinary bladder and renal pelvis were observed in male and female rats. No clear evidence for an increased incidence of treatment-related tumours was seen in mice.

No data were available to evaluate the reproductive effects or prenatal toxicity of 11-aminoundecanoic acid to experimental animals.

11-Aminodecanoic acid was not mutagenic to Drosophila melanogaster.

5.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of 11-aminoundecanoic acid to humans.

No case report or epidemiological study was available to evaluate the carcinogenicity of 11-aminoundecanoic acid to humans.

5.4 Evaluation

There is limited evidence for the carcinogenicity of 11-aminoundecanoic acid in experimental animals.

No data on humans were available.

In the absence of epidemiological data, no evaluation of the carcinogenicity of 11-aminoundecanoic acid to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 3)

Synonyms


Last updated: 21 April 1998






















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