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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

2,6-DICHLORO-para-PHENYLENEDIAMINE

VOL.: 39 (1986) (p. 325)

CAS No.: 609-20-1
Chem. Abstr. Name: 1,4-Benzenediamine, 2,6-dichloro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

2,6-Dichloro-para-phenylenediamine has been used to a limited extent as an intermediate in dye and resin manufacture. The main potential for exposure derives from its formation as a metabolite of the pesticide 2,6-dichloro-4-nitroaniline.

4.2 Experimental data

2,6-Dichloro-para-phenylenediamine was tested in mice and rats by oral administration in the diet. Increased numbers of liver-cell tumours were observed in mice; no treatment-related tumour was found in rats.

No data were available to evaluate the reproductive effects or prenatal toxicity of 2,6-dichloro-para-phenylenediamine to experimental animals.

2,6-Dichloro-para-phenylenediamine was mutagenic to Salmonella typhimurium in the presence and absence of an exogenous metabolic system.

4.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of 2,6-dichloro-para-phenylenediamine to humans.

No case report or epidemiological study was available to evaluate the carcinogenicity of 2,6-dichloro-para-phenylenediamine to humans.

4.4 Evaluation

There is limited evidence for the carcinogenicity of 2,6-dichloro-para-phenylenediamine to experimental animals.

No data on humans were available.

In the absence of epidemiological data, no evaluation of the carcinogenicity of 2,6-dichloro-para-phenylenediamine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 3)

Synonyms


Last updated: 21 April 1998






















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