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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DICHLOROACETYLENE

VOL.: 39 (1986) (p. 369)

CAS No.: 7572-29-4
Chem. Abstr. Name: Ethyne, dichloro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Dichloroacetylene is not available commercially. It can be formed from the decomposition of trichloroethylene.

5.2 Experimental data

Dichloroacetylene was tested for carcinogenicity in mice and rats by inhalation. Treatment-related increases were observed in the incidence of adenocarcinomas of the kidney in male mice. In rats, the occurrence of benign tumours of the liver and kidney and an increased incidence of lymphomas were reported.

No data were available to evaluate the reproductive effects or prenatal toxicity of dichloroacetylene to experimental animals.

Dichloroacetylene and one of its decomposition products, trichloroacryloyl chloride, were mutagenic to Salmonella typhimurium in the presence or absence of an exogenous metabolic system. Under the same conditions a mixture of dichloroacetylene and acetylene was not mutagenic.

5.3 Human data

Dichloroacetylene is a neurotoxin, with a special affinity for the cranial nerves. No data were available to evaluate the reproductive effects or prenatal toxicity of dichloroacetylene to humans.

No case report or epidemiological study was available to evaluate the carcinogenicity of dichloroacetylene to humans.

5.4 Evaluation

There is limited evidence for the carcinogenicity of dichloroacetylene to experimental animals.

No data on humans were available.

In the absence of epidemiological data, no evaluation of the carcinogenicity of dichloroacetylene to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonym


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       Dichloroacetylene (ICSC)
       Dichloroacetylene  (IARC Summary & Evaluation, Volume 71, 1999)