International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 39 (1986) (p. 333)
CAS No.: 108-78-1
Chem. Abstr. Name: 1,3,5-Triazine-2,4,6-triamine
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Melamine has been available commercially since the late 1930s.
Occupational exposure to this compound may occur during its production
and use in the manufacture of laminates, surface coatings, moulding
compounds and textiles. No measurement of such exposure was available
to the Working Group.
5.2 Experimental data
Melamine was tested for carcinogenicity by oral administration in
the diet in one study in mice and in one study in rats, and for
initiating activity by skin application in one study in mice. No
neoplasm related to treatment was observed after oral administration
to mice. Male rats fed diets containing melamine developed
transitional-cell tumours of the urinary bladder; with one exception,
all tumour-bearing animals had bladder stones probably consisting of
melamine. This finding precluded a clear interpretation of the
results. In a two-stage mouse-skin assay in which melamine was tested
at one dose level, it did not show initiating activity.
The available data were inadequate to evaluate the reproductive
effects or prenatal toxicity of melamine to experimental animals.
Melamine was not mutagenic to Salmonella typhimurium in the
presence or absence of an exogenous metabolic system nor was it
mutagenic to Drosophila melanogaster.
5.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of melamine to humans.
No case report or epidemiological study was available to evaluate
the carcinogenicity of melamine to humans.
There is inadequate evidence for the carcinogenicity of melamine
to experimental animals.
No data on humans were available.
In the absence of epidemiological data, no evaluation of the
carcinogenicity of melamine to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 65); Vol. 73 (1999)
- Cyanuric triamide
- Hicophor PR
- 1,3,5-Triazine 2,4,6(1H,3H,5H)-triimine
- Virset 656-4
Last updated: 30 September 1999