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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

METHYL ACRYLATE

VOL.: 39 (1986) (p. 99)

CAS No.: 96-33-3
Chem. Abstr. Name: 2-Propenoic acid, methyl ester

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Methyl acrylate has been available commercially since 1944. Occupational exposure may occur during its use, primarily as a comonomer with acrylonitrile in the preparation of acrylic and modacrylic fibres. No data on occupational exposure to this compound were available to the Working Group.

5.2 Experimental data

In one study reported as an abstract, in which rats were exposed to methyl acrylate by inhalation for two years, no neoplastic effect was reported.

No data were available to evaluate the reproductive effects or prenatal toxicity of methyl acrylate to experimental animals.

Methyl acrylate was not mutagenic to bacteria, in the presence or absence of an exogenous metabolic system. It induced chromosomal aberrations in Chinese hamster lung cells in vitro and micronuclei in the bone marrow of mice treated in vivo.

5.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of methyl acrylate to humans.

No case report or epidemiological study was available to evaluate the carcinogenicity of methyl acrylate to humans.

5.4 Evaluation

There is inadequate evidence for the carcinogenicity of methyl acrylate to experimental animals.

No data on humans were available.

In the absence of epidemiological data, no evaluation of the carcinogenicity of methyl acrylate to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 19 (1979)

Subsequent evaluation: Vol. 71 (1999)

Synonyms


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       Methyl acrylate (ICSC)
       Methyl Acrylate  (IARC Summary & Evaluation, Volume 71, 1999)