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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

VINYLIDENE FLUORIDE

VOL.: 39 (1986) (p. 227)

CAS No.: 75-38-7
Chem. Abstr. Name: Ethene, 1,1-difluoro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Vinylidene fluoride has been produced commercially since the 1940s. It is used in the manufacture of polyvinylidene fluoride and elastomeric copolymers. Exposure is limited to the manufacture of the monomer and its use in the production of polyvinylidene fluoride and elastomeric copolymers.

5.2 Experimental data

In a limited study in one strain of rats by oral administration, a small number of liposarcomas was observed in treated animals.

No data were available to evaluate the reproductive effects or prenatal toxicity of vinylidine fluoride to experimental animals.

Vinylidene fluoride gave equivocal results for mutagenicity to Salmonella typhimurium when tested in the presence of an exogenous metabolic system.

5.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of vinylidine fluoride to humans.

No case report or epidemiological study was available to evaluate the carcinogenicity of vinylidene fluoride to humans.

5.4 Evaluation

There is inadequate evidence for the carcinogenicity of vinylidene fluoride in experimental animals.

No data on humans were available.

In the absence of epidemiological data, no evaluation of the carcinogenicity of vinylidene fluoride to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonym


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       Vinylidene fluoride (ICSC)
       Vinylidene Fluoride  (IARC Summary & Evaluation, Volume 71, 1999)