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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

A-a-C (2-AMINO-9H-PYRIDO[2,3-b]INDOLE)

VOL.: 40 (1986) (p. 245)

CAS No.: 26148-68-5
Chem. Abstr. Name: 1H-Pyrido[2,3-b]indo1-2-amine

5. Summary of Data Reported and Evaluation

5.1 Exposure

A-a-C (2-amino-9H-pyrido[2,3-b]indole) has been found in a variety in grilled foods, in the pyrolysis products of proteins and in cigarette smoke. There is thus likely to be widespread human exposure to this compound.

5.2 Experimental data

A-a-C was tested for carcinogenicity in one experiment in mice by oral administration in the diet. It produced haemangioendothelial sarcomas and hepatocellular adenomas and carcinomas in animals of each sex.

No data were available to evaluate the reproductive effects or prenatal toxicity of this compound to experimental animals.

A-a-C induced prophage in bacteria. It induced DNA damage in Bacillus subtilis and mutations in Salmonella typhimurium in the presence of an exogenous metabolic system. It gave positive results in the wing spot test in Drosophila melanogaster. In cultured Chinese hamster lung cells, A-a-C induced mutations and chromosomal aberrations in the presence and polyploidy in the absence, of an exogenous metabolic system. It induced sister chromatid exchanges in human lymphoblastoid cells.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of A-a-C was available to the Working Group.

5.4 Evaluation

There is sufficient evidence for the carcinogenicity of A-a-C to experimental animals.

No data were available on the carcinogenicity of A-a-C to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 56: Group 2B)

Synonyms


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