VOL.: 40 (1986) (p. 161)
Chem. Abstr. Name: 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
Butylated hydroxytoluene was studied in mice and rats for its ability to modify the carcinogenicity of selected chemical agents. When administered with known carcinogens, butylated hydroxytoluene either enhanced, inhibited or had no effect on carcinogenicity.
No adequate data were available to evaluate the reproductive effects or prenatal toxicity of butylated hydroxytoluene to experimental animals.
In mice, a single intraperitoneal dose or feeding of butylated hydroxytoluene can cause pulmonary alveolar cell necrosis and proliferation. Butylated hydroxytoluene also induces proliferation of smooth endoplasmic reticulum in rat-liver cells, leading to hepatomegaly.
Butylated hydroxytoluene did not induce DNA damage in Bacillus subtilis or mutation in Salmonella typhimurium. It did not induce chromosomal aberrations in plants or mutation or chromosomal aberrations in Drosophila melanogaster. In one study, it was reported to be mutagenic to cultured Chinese hamster cells in the presence of an exogenous metabolic system. Binding of butylated hydroxytoluene to the DNA of liver of rats treated in vivo has been reported. It did not induce micronuclei in bone marrow or dominant lethal mutations in mice. It induced sperm abnormalities in mice.
When tested in combination with other chemicals (usually, known mutagens or carcinogens), butylated hydroxytoluene often modified the DNA-damaging, mutagenic and clastogenic activities. In most studies, butylated hydroxytoluene reduced the activity of indirectly-acting mutagens or carcinogens.
No evaluation could be made of the carcinogenicity of butylated hydroxytoluene to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 59: Group 3)
See Also: Toxicological Abbreviations Butylated hydroxytoluene (BHT) (WHO Food Additives Series 15) Butylated hydroxytoluene (BHT) (WHO Food Additives Series 18) Butylated hydroxytoluene (BHT) (WHO Food Additives Series 28) Butylated hydroxytoluene (BHT) (WHO Food Additives Series 42)