International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 40 (1986) (p. 222)
CAS No.: 67730-11-4
Chem. Abstr. Name: 6-Methyldipyrido[1,2-a:3',2'-d]imidazol-2-amine
5. Summary of Data Reported and Evaluation
Glu-P-1 (2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole) is found at
low levels among the pyrolysis products of L-glutamic acid and casein,
and human exposure may occur by ingestion of cooked foods containing
5.2 Experimental data
Glu-P-1 was tested for carcinogenicity in one experiment in mice and
one experiment in rats by oral administration in the diet. It produced
haemangioendotheliomas and haemangioendothelial sarcomas at various
sites and hepatocellular adenomas in mice of each sex and liver
carcinomas in female mice. In rats, it produced benign and malignant
tumours of the liver, intestines and Zymbal gland in animals of each
sex and tumours of the clitoral gland in females.
No data were available to evaluate the reproductive effects or
prenatal toxicity of this compound to experimental animals.
Glu-P-1 induced prophage in bacteria. It was mutagenic in Salmonella
typhimurium in the presence of an exogenous metabolic system, and gave
positive results in the wing spot test in Drosophila melanogaster.
Glu-P-1 induced mutations, chromosomal aberrations, sister chromatid
exchanges and morphological transformation in cultured mammalian
cells. It induced DNA damage in rats treated in vivo and positive
results in the mouse spot test.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
Glu-P-1 was available to the Working Group.
There is sufficient evidence for the carcinogenicity of Glu-P-1 to
No data were available on the carcinogenicity of Glu-P-1 to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 2B)
Last updated: 23 April 1998