International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 40 (1986) (p. 235)
CAS No.: 67730-10-3
Chem. Abstr. Name: Dipyrido[1,2-a:3',2'-d]imidazo1-2-amine
5. Summary of Data Reported and Evaluation
Glu-P-2 (2-aminodipyrido[1,2-a:3',2'-d]imidazole) has been found in
grilled fish and in L-glutamic acid and casein pyrolysates;
therefore, consumption of grilled foods may result in human exposure.
5.2 Experimental data
Glu-P-2 was tested for carcinogenicity in one experiment in mice and
one experiment in rats by oral administration in the diet. In mice, it
produced haemangioendotheliomas and haemangioendothelial sarcomas at
various sites and hepatocellular adenomas and carcinomas in animals of
each sex. In rats, it produced benign and malignant tumours of the
liver, intestines and zymbal gland in animals of each sex and
tumours of the clitoral gland in females.
No data were available to evaluate the reproductive effects or
prenatal toxicity of this compound to experimental animals.
Glu-P-2 induced prophage in bacteria. It was mutagenic in Salmonella
typhimurium in the presence of an exogenous metabolic system and in
cultured mammalian cells, and gave positive results in the wing spot
test in Drosophila melanogaster. Experiments for the induction of
sister chromatid exchanges and chromosomal aberrations in cultured
mammalian cells were inadequate.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
Glu-P-2 was available to the Working Group.
There is sufficient evidence for the carcinogenicity of Glu-P-2 to
No data were available on the carcinogenicity of Glu-P-2 to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 2B)
- 2-Aminodipyrido[ 1,2-a:3',2'-d]imidazole
Last updated: 22 April 1998