VOL.: 40 (1986) (p. 207)
Chem. Abstr. Name: Bromic acid, potassium salt
The incidence of renal-cell tumours in rats induced by administration
hydroxyethylamine was increased by subsequent administration of potassium bromate.
In rats, administration of potassium bromate in the drinking-water caused tubular lesions of the kidney which were classified as dysplastic foci.
No data were available to evaluate the reproductive effects or prenatal toxicity of potassium bromate to experimental animals.
Potassium bromate was mutagenic in Salmonella typhimurium in the presence of an exogenous metabolic system. The compound induced chromosomal aberrations in cultured Chinese hamster cells and micronuclei in mice treated in vivo.
No data were available on the carcinogenicity of potassium bromate to humans.
N.B. - After the meeting, the Secretariat became aware of a study in which 9% of male hamsters administered potassium bromate in the drinking-water developed kidney tumours (Takamura et al., 1986).
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluations: Suppl. 7 (1987) (p. 70); Vol. 73 (1999)
See Also: Toxicological Abbreviations Potassium bromate (ICSC) Potassium bromate (WHO Food Additives Series 18) Potassium bromate (WHO Food Additives Series 24) Potassium bromate (WHO Food Additives Series 30) POTASSIUM BROMATE (JECFA Evaluation)