International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 40 (1986) (p. 99)
CAS No.: 23537-16-8
5. Summary of Data Reported and Evaluation
Rugulosin is a mycotoxin produced by certain fungal species that can
contaminate cereal grains. Human exposure may occur by the ingestion
of contaminated grain products.
5.2 Experimental data
Rugulosin was tested for carcinogenicity in two experiments in male
mice by oral administration in the diet. Both experiments were
considered to be inadequate for evaluation.
No data were available to evaluate the reproductive effects or
prenatal toxicity of rugulosin.
Rugulosin induced DNA damage in Bacillus subtilis. It did not induce
reverse mutations in Salmonella typhimurium but was reported to induce
forward mutations. It did not induce mutations in Escherichia coli. It
induced cytoplasmic petite mutations in yeast. Rugulosin did not
induce unscheduled DNA synthesis in mammalian cells in vitro.
5.3 Human data
No case report or epidemiological study of the carcinogenicity of
rugulosin was available to the Working Group.
There is inadequate evidence for the carcinogenicity of rugulosin in
No evaluation could be made of the carcinogenicity of rugulosin to
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 71: Group 3)
Last updated: 22 April 1998