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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

RUGULOSIN

VOL.: 40 (1986) (p. 99)

CAS No.: 23537-16-8

5. Summary of Data Reported and Evaluation

5.1 Exposure

Rugulosin is a mycotoxin produced by certain fungal species that can contaminate cereal grains. Human exposure may occur by the ingestion of contaminated grain products.

5.2 Experimental data

Rugulosin was tested for carcinogenicity in two experiments in male mice by oral administration in the diet. Both experiments were considered to be inadequate for evaluation.

No data were available to evaluate the reproductive effects or prenatal toxicity of rugulosin.

Rugulosin induced DNA damage in Bacillus subtilis. It did not induce reverse mutations in Salmonella typhimurium but was reported to induce forward mutations. It did not induce mutations in Escherichia coli. It induced cytoplasmic petite mutations in yeast. Rugulosin did not induce unscheduled DNA synthesis in mammalian cells in vitro.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of rugulosin was available to the Working Group.

5.4 Evaluation

There is inadequate evidence for the carcinogenicity of rugulosin in experimental animals.

No evaluation could be made of the carcinogenicity of rugulosin to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 71: Group 3)

Synonyms


Last updated: 22 April 1998






















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