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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

1,2-DICHLOROPROPANE

VOL.: 41 (1986) (p. 131)

CAS No.: 78-87-5

5. Summary of Data Reported and Evaluation

5.1 Exposure data

1,2-Dichloropropane has been used as an industrial solvent, as a chemical intermediate and in soil fumigants. Human exposure may occur during its production and industrial and domestic use, and due to the presence of low levels in ambient air and in water.

5.2 Experimental data

1,2-Dichloropropane was tested for carcinogenicity by oral administration by gavage in one experiment in mice and one experiment in rats. A dose-related increase in the incidence of hepatocellular tumours was observed in male and female mice. Inconclusive results were obtained with regard to female rats, and no effect was seen in male rats.

No data were available to evaluate the reproductive effects or prenatal toxicity of 1,2-dichloropropane to experimental animals.

1,2-Dichloropropane is mutagenic to Salmonella typhimurium but not to Streptomyces coelicolor. It induces mutations but not chromosomal effects in Aspergillus nidulans. It does not induce sex-linked recessive lethal mutations in Drosophila melanogaster.

5.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of 1,2-dichloropropane to humans.

No case report or epidemiological study on the carcinogenicity of 1,2-dichloropropane to humans was available to the Working Group.

5.4 Evaluation

There is limited evidence for the carcinogenicity of 1,2-dichloropropane to experimental animals.

No evaluation could be made of the carcinogenicity of 1,2-dichloropropane to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol.71 (1999)

Synonyms


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       Dichloropropane, 1,2- (IARC Summary & Evaluation, Volume 71, 1999)