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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

2-CHLORO-1,1,1-TRIFLUOROETHANE

VOL.: 41 (1986) (p. 253)

CAS No.: 75-88-7

5. Summary of Data Reported and Evaluation

5.1 Exposure data

2-Chloro-1,1,1-trifluoroethane is used as a chemical intermediate in the production of the anaesthetic halothane. Human exposure occurs due to its presence as a low-level impurity in, and at metabolite of, halothane.

5.2 Experimental data

2-Chloro-1,1,1-trifluoroethane was tested for carcinogenicity in one experiment in rats by oral administration by gavage at one dose level. Increased incidences of uterine carcinomas and benign testicular tumours were observed.

No data were available to evaluate the reproductive effects or prenatal toxicity of 2-chloro-1,1,1-trifluoroethane to experimental animals.

2-Chloro-1,1,1-trifluoroethane is not mutagenic to Salmonella typhimurium in the presence or absence of an exogenous metabolic system.

5.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of 2-chloro-1,1,1-trifluoroethane to humans.

No case report or epidemiological study of the carcinogenicity of 2-chloro-1,1,1-trifluoroethane to humans was available to the Working Group.

5.4 Evaluation

There is limited evidence for the carcinogenicity of 2-chloro-1,1,1-trifluoroethane to experimental animals.

No evaluation could be made of the carcinogenicity of 2-chloro-1,1,1-trifluoroethane to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonyms


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       2-Chloro-1,1,1-trifluoroethane  (IARC Summary & Evaluation, Volume 71, 1999)