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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BIS(2-CHLORO-1-METHYLETHYL)ETHER

VOL.: 41 (1986) (p. 149)

CAS No.: 108-60-1
Chem. Abstr. Name: 2,2'-Oxybis(1-chloropropane)

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Bis(2-chloro-1-methylethyl)ether has been produced as a solvent and soil fumigant and is also formed in large quantities as a by-product in some propylene oxide/propylene glycol production processes. Low levels have been found in water. Thus, both occupational and environmental exposures may occur.

5.2 Experimental data

Bis(2-chloro-1-methylethyl)ether, containing 2-chloro-1-methylethyl(2-chloro-n-propyl)ether and bis(2-chloro-n-propyl)ether, was tested for carcinogenicity by oral administration by gavage in one experiment in mice and in one experiment in rats. In mice, increased incidences of lung adenomas in males and females and of hepatocellular carcinomas in males were observed. In rats, no increase in tumour incidence was observed.

No data were available to evaluate the reproductive or prenatal effects of bis(2-chloro-1-methylethyl)ether to experimental animals.

Bis(2-chloro-1-methylethyl)ether is mutagenic to Salmonella typhimurium. It does not induce sex-linked recessive lethal mutations in Drosophila melanogaster.

4.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of bis(2-chloro-1-methylethyl)ether to humans.

No case report or epidemiological study of the carcinogenicity of bis(2-chloro-1-methylethyl)ether to humans was available to the Working Group.

4.4 Evaluation

There is limited evidence for the carcinogenicity of bis(2-chloro-1-methylethyl)ether to experimental animals.

No evaluation could be made of the carcinogenicity of bis(2-chloro-1-methylethyl)ether to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonyms


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       Bis(2-chloro-1-methylethyl)ether  (IARC Summary & Evaluation, Volume 71, 1999)