VOL.: 41 (1986) (p. 261)
Short-term exposures of rats to high doses of commercial preparations of polybrominated biphenyls induce embryonic death, growth retardation and malformation; malformations have not been observed following exposure to lower doses throughout gestation. Pre- and perinatal exposure of rats to polybrominated biphenyls reduces postnatal growth and viability.
Various commercial preparations of polybrominated biphenyls are not mutagenic to bacteria in the presence or absence of exogenous metabolic systems or in a host-mediated assay. Polybrominated biphenyls do not induce DNA damage, or mutation, in cultured mammalian cells or chromosomal aberrations in rat or mouse bone marrow, nor micronuclei in mouse bone marrow, but they do inhibit junctional intercellular communication in cultured mammalian cells.
A small cohort study of chemical workers potentially exposed to polybrominated biphenyls together with other chemicals was uninformative with regard to cancer.
There is inadequate evidence for the carcinogenicity of polybrominated biphenyls to humans.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 18 (1978)
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations Polybrominated biphenyls (EHC 152, 1994)