For definition of Groups, see Preamble Evaluation.
VOL.: 46 (1989) (p. 201)
Chem. Abstr. Name: Pyrene, 1,3-dinitro-
1,3-Dinitropyrene has been detected in some carbon blacks and in particulate emissions from diesel engines, kerosene heaters and gas burners. It has been found at low concentrations in ambient air.
1,3-Dinitropyrene was tested for carcinogenicity in single experiments in rats by oral administration, in mice, rats and newborn rats by subcutaneous injection and in newborn mice and in weanling rats by intraperitoneal injection. It was carcinogenic to rats, producing sarcomas at the site of its subcutaneous injection. The tests by oral and intraperitoneal routes in rats and by subcutaneous and intraperitoneal injection in mice were inadequate for evaluation.
No data were available to the Working Group.
Metabolism of 1,3-dinitropyrene led to DNA binding in vitro. 1,3-Dinitropyrene caused DNA damage and mutation in cultured rodent and human cells and in bacteria. It did not cause gene conversion in yeast.
There is limited evidence for the carcinogenicity in experimental animals of 1,3-dinitropyrene.
No data were available from studies in humans on the carcinogenicity of 1,3-dinitropyrene.
1,3-Dinitropyrene is not classifiable as to its carcinogenicity to humans (Group 3).
For definition of the italicized terms, see Preamble Evaluation.
Last updated 01/21/98
See Also: Toxicological Abbreviations