For definition of Groups, see Preamble Evaluation.
VOL.: 46 (1989) (p. 277)
Chem. Abstr. Name: 9H-Fluorene, 2-nitro-
2-Nitrofluorene has been detected in particulate emissions from diesel engines, kerosene heaters and gas burners. It has also been found at low concentrations in ambient air.
2-Nitrofluorene was tested for carcinogenicity in rats by oral administration, producing tumours of the mammary gland, forestomach, liver and ear duct. In a liver initiation-promotion model, it was shown to be an initiator of preneoplastic foci.
No data were available to the Working Group.
2-Nitrofluorene induced sister chromatid exchange in Chinese hamsters in vivo. It induced DNA damage, sister chromatid exchange, mutation and morphological transformation in cultured animal cells. It was recombinogenic but not mutagenic to fungi and induced DNA damage and mutation in bacteria.
2-Aminofluorene, 2-acetylaminofluorene, N-hydroxy-2-amino-fluorene and N-hydroxy-2-acetylaminofluorene, which are model carcinogens, have been detected as metabolites of 2-nitrofluorene.
There is sufficient evidence for the carcinogenicity in experimental animals of 2-nitrofluorene.
No data were available from studies in humans on the carcinogenicity of 2-nitrofluorene.
2-Nitrofluorene is possibly carcinogenic to humans (Group 2B).
Last updated 01/21/98
See Also: Toxicological Abbreviations