For definition of Groups, see Preamble Evaluation.
VOL.: 48 (1990) (p. 109)
Chem. Abstr. Name: Tris(2-chloroethyl)phosphate
Tris(2-chloroethyl) phosphate is used as a flame retardant in plastics, especially in flexible foams used in automobiles and furniture, and in rigid foams used for building insulation. No data on occupational exposure levels were available. Tris(2-chloroethyl) phosphate has been detected in drinking-water, river water, sea water and sediments in various parts of the world.
Tris(2-chloroethyl) phosphate was tested for initiating and promoting activity and for complete carcinogenicity in one strain of mice by skin application. No initiating activity was found; promoting activity and complete carcinogenicity could not be evaluated.
No data were available to the Working Group.
In single studies, tris(2-chloroethyl) phosphate gave equivocal results in a micronucleus test in Chinese hamsters in vivo and caused dominant lethal mutation in rats. It caused cell transformation and, in single studies, sister chromatid exchange but not mutation in rodent cells in vitro. It was not mutagenic to bacteria in the absence of an exogenous metabolic system but gave equivocal results in the presence of an exogenous metabolic system.
There is inadequate evidence for the carcinogenicity of tris(2-chloroethyl) phosphate in experimental animals.
No data were available from studies in humans on the carcinogenicity of tris(2-chloro-ethyl) phosphate.
Tris(2-chloroethyl) phosphate is not classifiable as to its carcinogenicity to humans (Group 3).
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
Last updated: 13 April 1999
See Also: Toxicological Abbreviations Tris(2-chloroethyl) phosphate (ICSC) Tris(2-chloroethyl) Phosphate (IARC Summary & Evaluation, Volume 71, 1999)