International Agency for Research on Cancer (IARC) - Summaries & Evaluations
For definition of Groups, see Preamble Evaluation.
VOL.: 48 (1990) (p. 169)
CAS No.: 99-55-8
Chem. Abstr. Name: Benzenamine, 2-methyl-5-nitro-
5. Summary of Data Reported and Evaluation
5.1 Exposure data
5-Nitro-ortho-toluidine is used as an intermediate in the
production of a wide assortment of pigments and azo dyes. No data
on occupational exposure levels were available.
5.2 Experimental carcinogenicity data
5-Nitro-ortho-toluidine was tested for carcinogenicity
by oral administration in one strain of mice and in one strain
of rats. It produced an increase in the incidence of hepatocellular
tumours in mice of each sex and a marginal increase in the incidence
of hepatocellular carcinomas in male rats.
5.3 Human carcinogenicity data
No data were available to the Working Group.
5.4 Other relevant data
5-Nitro-ortho-toluidine was mutagenic to bacteria in the
presence and absence of an exogenous metabolic system.
There is limited evidence for the carcinogenicity of 5-nitro-ortho-toluidine
in experimental animals.
No data were available from studies in humans on the carcinogenicity
5-Nitro-ortho-toluidine is not classifiable as to its
carcinogenicity to humans (Group 3).
For definition of the italicized terms, see Preamble Evaluation.
- Amarthol Fast Scarlet G Base
- Amarthol Fast Scarlet G Salt
- Azoene Fast Scarlet GC Base
- Azoene Fast Scarlet GC Salt
- Azofix Scarlet G Salt
- Azogene Fast Scarlet G
- Azoic diazo component 12
- Dainichi Fast Scarlet G Base
- Daito Scarlet Base G
- Devol Scarlet B
- Devol Scarlet G Salt
- Diabase Scarlet G
- Diazo Fast Scarlet G
- Fast Red SG Base
- Fast Scarlet G
- Fast Scarlet G Base
- Fast Scarlet G Salt
- Fast Scarlet GC Base
- Fast Scarlet J Base
- Fast Scarlet J Salt
- Fast Scarlet M 4NT Base
- Fast Scarlet T Base
- Hiltonil Fast Scarlet G Base
- Hiltonil Fast Scarlet G Salt
- Hiltonil Fast Scarlet GC Base
- Kayaku Scarlet G Base
- Lake Scarlet G Base
- Lithosol Orange R Base
- Mitsui Scarlet G Base
- Naphthanil Scarlet G Base
- Naphtoelan Fast Scarlet G Base
- Naphtoelan Fast Scarlet G Salt
- Scarlet Base Ciba II
- Scarlet Base Irga II
- Scarlet base NSP
- Scarlet G Base
- Sugai Fast Scarlet G Base
- Symulon Scarlet G Base
Last updated 01/20/98