For definition of Groups, see Preamble Evaluation.
VOL.: 56 (1993) (p. 467)
CAS No.:
Chem. Abstr. Name: Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy,
4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-
T-2 Toxin is produced primarily by Fusarium sporotrichioides, which occurs rarely on cereals such as wheat and maize. The toxin is considered to have played a role in largescale human poisonings in Siberia during this century.
No data were available to the Working Group.
T-2 Toxin was tested for carcinogenicity in mice and in trout by oral administration in the diet and in rats by intragastric administration. In mice, it increased the incidences of pulmonary and hepatic adenomas in males. The studies in trout and rats were inadequate for evaluation.
T-2 Toxin causes outbreaks of haemorrhagic disease in animals and has been associated with alimentary toxic aleukia in humans.
No data were available on the genetic and related effects of T-2 toxin in humans.
Experimental data were drawn mainly from single studies. T-2 Toxin induced DNA damage and chromosomal aberrations in rodents in vivo, in cultured human cells and in cultured rodent cells. It inhibited protein synthesis in various mammalian and human cell types in vitro. Chromosomal aberrations were also induced in insects. It induced gene mutation in cultured rodent cells but not in bacteria. It did not induce DNA damage in bacteria.
No data were available on the carcinogenicity to humans of toxins derived from Fusarium sporotrichioides.
There is limited evidence in experimental animals for the carcinogenicity of T-2 toxin.
Toxins derived from Fusarium sporotrichioides are not
classifiable as to their carcinogenicity to humans
(Group 3).
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Suppl. 7 (1987) (p. 73)
See Also:
Toxicological Abbreviations