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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

TOXINS DERIVED FROM FUSARIUM SPOROTRICHIOIDES:
T-2 TOXIN
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 56 (1993) (p. 467)
CAS No.: 21259-20-1
Chem. Abstr. Name: Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

T-2 Toxin is produced primarily by Fusarium sporotrichioides, which occurs rarely on cereals such as wheat and maize. The toxin is considered to have played a role in largescale human poisonings in Siberia during this century.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

T-2 Toxin was tested for carcinogenicity in mice and in trout by oral administration in the diet and in rats by intragastric administration. In mice, it increased the incidences of pulmonary and hepatic adenomas in males. The studies in trout and rats were inadequate for evaluation.

5.4 Other relevant data

T-2 Toxin causes outbreaks of haemorrhagic disease in animals and has been associated with alimentary toxic aleukia in humans.

No data were available on the genetic and related effects of T-2 toxin in humans.

Experimental data were drawn mainly from single studies. T-2 Toxin induced DNA damage and chromosomal aberrations in rodents in vivo, in cultured human cells and in cultured rodent cells. It inhibited protein synthesis in various mammalian and human cell types in vitro. Chromosomal aberrations were also induced in insects. It induced gene mutation in cultured rodent cells but not in bacteria. It did not induce DNA damage in bacteria.

5.5 Evaluation

No data were available on the carcinogenicity to humans of toxins derived from Fusarium sporotrichioides.

There is limited evidence in experimental animals for the carcinogenicity of T-2 toxin.

Overall evaluation

Toxins derived from Fusarium sporotrichioides are not classifiable as to their carcinogenicity to humans
(Group 3)
.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Suppl. 7 (1987) (p. 73)

Synonyms


Last updated 08/21/1997






















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       Toxicological Abbreviations