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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CI ACID ORANGE 3
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 121)
CAS No.: 6373-74-6
Chem. Abstr. Name: 5-[(2,4-Dinitrophenyl)amino]-2-(phenylamino)benzene-sulfonic acid, monosodium salt

5. Summary of Data Reported and Evaluation

5.1 Exposure data

CI Acid Orange 3 is used to a limited extent as a dye in semi-permanent hair colouring products and in the dyeing of textiles.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

CI Acid Orange 3 was tested for carcinogenicity by gavage in one study in mice and in one study in rats. In mice, there was no significant increase in the incidence of tumours. A significant increase in the incidence of transitional-cell carcinomas of the renal pelvis was observed in female rats given the high dose. The data on high-dose male rats could not be evaluated owing to their poor survival.

5.4 Other relevant data

CI Acid Orange 3 caused renal toxicity in rats and mice. It was mutagenic to bacteria.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of CI Acid Orange 3.

There is limited evidence in experimental animals for the carcinogenicity of CI Acid Orange 3.

Overall evaluation

CI Acid Orange 3 is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms


Last updated 08/22/1997






















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       Toxicological Abbreviations