For definition of Groups, see Preamble Evaluation.
VOL.: 57 (1993) (p. 153)
Chem. Abstr. Name: 2-[(4-Amino-2-nitrophenyl)amino]ethanol
HC Red No. 3 is used as a semipermanent hair dye.
No data were available to the Working Group.
HC Red No. 3 was tested for carcinogenicity by gavage in one study in mice and in one study in rats. There was a significant increase in the incidence of hepatocellular adenomas and carcinomas combined in male mice administered the high dose; poor survival precluded evaluation of the females. No increase in the incidence of treatment-related tumours was seen in rats of either sex.
HC Red No. 3 was mutagenic to bacteria.
There is inadequate evidence in humans for the carcinogenicity of HC Red No. 3.
There is inadequate evidence in experimental animals for the carcinogenicity of HC Red No. 3.
HC Red No. 3 is not classifiable as to its carcinogenicity to humans (Group 3).
For definition of the italicized terms, see Preamble Evaluation.
See Also: Toxicological Abbreviations