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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

2-AMINO-5-NITROPHENOL
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 177)
CAS No.: 121-88-0
Chem. Abstr. Name: 2-Amino-5-nitrophenol

5. Summary of Data Reported and Evaluation

5.1 Exposure data

2-Amino-5-nitrophenol is used as an intermediate in the manufacture of certain azo dyes. It is also used in semi-permanent and permanent hair colouring products.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

2-Amino-5-nitrophenol was tested for carcinogenicity by gavage in one study in mice and one study in rats. In mice, no significant increase in tumour incidence was observed in the low-dose groups; data on the high-dose groups could not be evaluated owing to high mortality rates. An increased incidence of pancreatic acinar-cell tumours was observed in male rats.

5.4 Other relevant data

Oral treatment with 2-amino-5-nitrophenol was associated with inflammation of the lower intestinal tract in mice and rats.

2-Amino-5-nitrophenol induced gene mutation in bacteria and gene mutation, sister chromatid exchange and chromosomal aberrations in cultured mammalian cells. It did not induce dominant lethal mutation in rats.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of 2-amino-5-nitrophenol.

There is limited evidence in experimental animals for the carcinogenicity of 2-amino-5-nitrophenol.

Overall evaluation

2-Amino-5-nitrophenol is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms


Last updated 08/22/1997






















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