For definition of Groups, see Preamble Evaluation.
VOL.: 57 (1993) (p. 247)
Chem. Abstr. Name: 8-[(3,3'-Dimethyl-4'-[(4-[([4-methylphenyl]sulfonyl)oxy]phenyl)azo][1,1'-biphenyl]-4-yl)azo]-7-hydroxy-
1,3-naphthalenedisulfonic acid, disodium salt
CI Acid Red 114, a bis-azo dye derived from 3,3'-dimethylbenzidine, is used to dye wool, silk, jute and leather.
No data were available to the Working Group.
CI Acid Red 114 was tested for carcinogenicity in one study in rats by administration in the drinking-water. It increased the incidences of benign and malignant tumours of the skin, Zymbal gland and liver in male and female rats, and of the clitoral gland, lung, oral cavity and small and large intestine in female rats.
Reductive cleavage of the azo bonds to yield 3,3'-dimethylbenzidine was demonstrated in vivo.
CI Acid Red 114 induced gene mutation in bacteria under reducing conditions. It did not induce gene mutation in insects or sister chromatid exchange or chromosomal aberrations in cultured mammalian cells.
There is inadequate evidence in humans for the carcinogenicity of CI Acid Red 114.
There is sufficient evidence in experimental animals for the carcinogenicity of CI Acid Red 114.
CI Acid Red 114 is possibly carcinogenic to humans (Group 2B).
For definition of the italicized terms, see Preamble Evaluation.
See Also: Toxicological Abbreviations