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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CI PIGMENT RED 3
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 259)
CAS No.: 2425-85-6
Chem. Abstr. Name: 1-[(4-Methyl-2-nitrophenyl)azo]-2-naphthalenol

5. Summary of Data Reported and Evaluation

5.1 Exposure data

CI Pigment Red 3, one of the most widely used red pigments, is found in paints, inks, plastics, rubber and textiles.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

CI Pigment Red 3 was tested for carcinogenicity by administration in the diet in one study in mice and in one study in rats. In male mice, it induced follicular-cell adenomas of the thyroid and renal-cell adenomas. There was an increased incidence of adrenal phaeochromocytomas in male rats and of hepatocellular adenomas in female rats.

5.4 Other relevant data

CI Pigment Red 3 did not induce gene mutation in bacteria or sister chromatid exchange or chromosomal aberrations in cultured mammalian cells.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of CI Pigment Red 3.

There is limited evidence in experimental animals for the carcinogenicity of CI Pigment Red 3.

Overall evaluation

CI Pigment Red 3 cannot be classified as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms


Last updated 08/22/1997






















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       Toxicological Abbreviations