For definition of Groups, see Preamble Evaluation.
VOL.: 57 (1993) (p. 305)
Chem. Abstr. Name: 4-Chlorobenzenamine
para-Chloroaniline is used as an intermediate in the manufacture of dyes, pigments, agricultural chemicals and pharmaceuticals. It is a persistent environmental degradation product of some herbicides and fungicides.
No data were available to the Working Group.
para-Chloroaniline was tested for carcinogenicity in mice and rats by administration in the diet and by gavage. It produced haemangiosarcomas in male and female mice in different organs after administration in the diet. It induced haemangiosarcomas of the spleen and liver and hepatocellular adenomas and carcinomas in male mice after administration by gavage. It induced sarcomas of the spleen and splenic capsule in male rats in both studies.
para-Chloroaniline causes methaemoglobinaemia and is metabolized similarly in humans and experimental animals.
para-Chloroaniline induced DNA damage in bacteria, but conflicting results were obtained for gene mutation. Gene mutation but not mitotic recombination was induced in fungi. Gene mutation, sister chromatid exchange and chromosomal aberrations were induced in cultured mammalian cells, while conflicting data were obtained for cell transformation.
There is inadequate evidence in humans for the carcinogenicity of para-chloroaniline.
There is sufficient evidence in experimental animals for the carcinogenicity of para-chloroaniline.
para-Chloroaniline is possibly carcinogenic to humans (Group 2B).
For definition of the italicized terms, see Preamble Evaluation.
See Also: Toxicological Abbreviations