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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

3,7-DINITROFLUORANTHENE AND
3,9-DINITROFLUORANTHENE
(Group 2B)

For definition of Groups, see Preamble Evaluation.

Vol.: 65 (1996) (p. 297)

CAS No.: 105735-71-5
Chem. Abstr. Name: 3,7-Dinitrofluoranthene

CAS No.: 22506-53-2
Chem. Abstr. Name: 3,9-Dinitrofluoranthene

5. Summary of Data Reported and Evaluation

5.1 Exposure data

3,7- and 3,9-Dinitrofluoranthenes are produced for laboratory use by nitration of fluoranthene. 3,7- and 3,9-Dinitrofluoranthenes have been detected at low levels in emissions from diesel engines, kerosene heaters and other combustion sources.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

3,7- and 3,9-Dinitrofluoranthenes were tested for carcinogenicity in rats by subcutaneous injection in one study and by pulmonary implantation in another study. Subcutaneous injection of 3,7- and 3,9-dinitrofluoranthenes induced a high incidence of subcutaneous tumours at the site of injection, most of which were malignant fibrous histiocytomas. Pulmonary implantation of 3,7- and 3,9-dinitrofluoranthenes induced a high incidence of lung tumours, most of which were squamous-cell carcinomas.

5.4 Other relevant data

3,7- and 3,9-Dinitrofluoranthenes are highly mutagenic to bacteria, particularly in the absence of an exogenous metabolic system. In mammalian cells in vitro, these compounds induced chromosomal aberrations but not gene mutations. In vivo, they induced micronuclei in mouse bone marrow.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of 3,7- and 3,9-dinitrofluoranthenes.

There is sufficient evidence in experimental animals for the carcinogenicity of 3,7- and 3,9-dinitrofluoranthenes.

Overall evaluation

3,7- and 3,9-Dinitrofluoranthenes are possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation

Previous evaluation

3,7-Dinitrofluoranthene: Vol. 46 (1989) (p. 189)

3,9-Dinitrofluoranthene: Vol. 46 (1989) (p. 195)


Last updated 08/14/1997






















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       Toxicological Abbreviations